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What is Imbruvica?

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Ibrutinib is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Ibrutinib is used to treat certain types of non-Hodgkin lymphoma, including mantle cell lymphoma (MCL), Waldenstrom’s macroglobulinemia, and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) in people with or without 17p deletion. Ibrutinib is sometimes given when other medicines have not been effective.

Ibrutinib was approved to treat mantle cell lymphoma by the US Food and Drug Administration (FDA) on an “accelerated” basis. In clinical studies, tumors responded to this medicine.

However, it has not been shown that ibrutinib can improve symptoms or lengthen survival time in people with this type of lymphoma. Ibrutinib may also be used for purposes not listed in this medication guide.

What is the most important information I should know about ibrutinib?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

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How should I take Imbruvica?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water. Drink plenty of liquids while you are taking ibrutinib. Ibrutinib is usually taken once per day.

Take the medicine at the same time each day. Do not crush, chew, break, or open an ibrutinib capsule. Swallow it whole. If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using ibrutinib.

You may need to stop using the medicine for a short time. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Imbruveca Side Effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using ibrutinib and call your doctor at once if you have: chest pain and severe dizziness, fast or irregular heartbeats, trouble breathing, feeling like you might pass out; severe or ongoing diarrhea; fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; severe weakness or dizziness, confusion, problems with speech, prolonged headache; signs of bleeding in your digestive tract–severe stomach pain, pink or brown urine, black or bloody stools, or if you cough up blood or vomit that looks like coffee grounds; signs of tumor cell breakdown–lower back pain, blood in your urine; numbness or tingly feeling around your mouth; muscle weakness or tightness; fast or slow heart rate, weak pulse; or kidney problems–little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath.

Common side effects may include: pale skin, easy bruising or bleeding; fever, chills, flu symptoms; nausea, diarrhea; tired feeling; rash; or muscle pain, bone pain.